Kids, Antibiotics and Kidney Stones

Kids, Antibiotics and Kidney Stones

Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

The lead author, Dr. Gregory E. Tasian, a urologist at the Children's Hospital of Philadelphia, said the mechanism is unclear, but that the most likely explanation is a complex interaction of the drugs with the urinary or gut microbiome.

Oral antibiotics could be responsible for the dramatic increase of kidney stones, according to a new study that covered 13 million people. Disruptions in the intestinal and urinary microbiome have been linked to the occurrence of kidney stones, but no previous studies revealed an association between antibiotic usage and stones. The risks for children under 18 were significantly higher than for adults.

Tasian and his colleagues are hoping to expand this research into broader, population-based studies to better understand how variations in microbiome composition may influence the development of kidney stones. While antibiotics are essential for stopping serious infections, Dr. Tasian says: "We should be using antibiotics appropriately and judiciously".

"Whenever I get a pain in the stomach, I think, 'Oh god kidney stones again, '" she says.

United States pediatric researchers found that children and adults treated with certain antibiotics had a greater risk of developing kidney stones.

Now, that the link has been established between antibiotics and stones. He says high-risk children, like those who've already had a kidney stone, should probably take antibiotics that are less associated with stones. They tracked antibiotic exposure three to 12 months before the diagnosis. Risks were increased 2.3 times, 1.9 times, 1.7 times, 1.7 times, and 1.3-times for sulfas, cephalosporins, fluoroquinolones, nitrofurantoin/methenamine, and broad-spectrum penicillins, respectively. The risk of kidney stones decreased over time but remained elevated several years after antibiotic use.

Conclusions Oral antibiotics associated with increased odds of nephrolithiasis, with the greatest odds for recent exposure and exposure at younger age. "The reasons for the increase are unknown, but our findings suggest that oral antibiotics play a role, especially given that children are prescribed antibiotics at higher rates than adults", said co-author Michelle Denburg from CHOP.